Expect tonight's game to be low scoring. Both Carolina and Denver sport solid defenses and the game is being played in the thin air at Mile High. My linear regression model has Carolina winning by 1.635 points so I will predict a 20 - 17 win for Carolina. Graham Gano wins it with a game winning FG or maybe Cam Newton runs it with less than 2 minutes to play. Regardless, this game should be a slugfest.
Personally I would stay away from betting this game against the spread but taking the under could be worthwhile. For daily fantasy sites (DFS), I would avoid all players tonight. Better value for the Sunday games. For traditional fantasy leagues, you should be fine with starting Cam Newton, Greg Olsen, and CJ Anderson. After that, I think you are reaching unless you drafted a crap squad!